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Our company mission is to bring the most intuitive and powerful tools to every PC gamer. These utilities range from File Attractors to Cleaners to Media Players and so much more. We also aim to include a wide variety of utilities in these categories to suit every user’s need.Stability of cetuximab added to irinotecan, 5-fluorouracil and leucovorin (FOLFIRI) for the first-line treatment of advanced colorectal cancer: a retrospective cohort study.
The combination of irinotecan, fluorouracil and leucovorin (FOLFIRI) is a standard treatment for advanced colorectal cancer. Cetuximab is an antibody directed against the epidermal growth factor receptor. This study evaluates the impact of cetuximab on the stability of FOLFIRI for the first-line treatment of advanced colorectal cancer. This retrospective cohort study included all patients treated with FOLFIRI between 2003 and 2005 in the Department of Oncology at Robert-Giffard Hospital, Boulogne-Billancourt, France. The primary endpoint was to determine the rate of protocol deviations defined as a decrease in the dose intensity of at least 20% or more during the first 8 weeks. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method and compared using log-rank test. Hazard ratio (HR) for PFS and OS was calculated using a Cox proportional hazards model. Seventy-four eligible patients (40 men and 34 women) were included. Their median age was 66 years and median follow-up was 21.2 months. Median relative dose intensity for irinotecan, 5-fluorouracil and leuc be359ba680
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